From: Subject: Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjects -- Frid et al. 82 (1): 69 -- American Journal of Clinical Nutrition Date: Thu, 5 Oct 2006 22:34:45 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C6E8CE.75914700" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2962 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C6E8CE.75914700 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: file://D:\Alternatieve geneeskunde 2005\Alternatieve geneeskunde\Amino's\Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjects -- Frid et al_.htm Effect of whey on blood glucose and insulin = responses to composite breakfast and lunch meals in type 2 diabetic = subjects -- Frid et al. 82 (1): 69 -- American Journal of Clinical = Nutrition
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3D""=20 Articles by Frid, A. H =
3D""=20 Articles by Bj=F6rck, I. M.=20 =
American Journal of Clinical Nutrition, Vol. 82, No. 1, 69-75, = July=20 2005
=A9 2005 American Society=20 for Clinical Nutrition

ORIGINAL RESEARCH COMMUNICATION

Effect of whey on blood glucose and insulin responses to composite = breakfast=20 and lunch meals in type 2 diabetic subjects1,2,3=20

Anders H Frid, Mikael=20 Nilsson, Jens Juul Holst and=20 Inger ME Bj=F6rck

1 From the Clinic of Endocrinology, = University=20 Hospital MAS, Malm=F6, Sweden (AHF); the Department of Applied Nutrition = and Food=20 Chemistry, Lund University, Lund, Sweden (MN and IMEB); and the = Department of=20 Medical Physiology, The Panum Institute, University of Copenhagen, = Copenhagen,=20 Denmark (JJH)

Background:Whey proteins have insulinotropic = effects and=20 reduce the postprandial glycemia in healthy subjects. The=20 mechanism is not known, but insulinogenic amino acids and the = incretin hormones seem to be involved.

Objective:The aim was to evaluate whether supplementation = of=20 meals with a high glycemic index (GI) with whey proteins may=20 increase insulin secretion and improve blood glucose control = in=20 type 2 diabetic subjects.

Design:Fourteen diet-treated subjects with type 2 diabetes = were=20 served a high-GI breakfast (white bread) and subsequent = high-GI=20 lunch (mashed potatoes with meatballs). The breakfast and = lunch=20 meals were supplemented with whey on one day; whey was = exchanged=20 for lean ham and lactose on another day. Venous blood samples = were drawn before and during 4 h after breakfast and 3 h = after=20 lunch for the measurement of blood glucose, serum insulin,=20 glucose-dependent insulinotropic polypeptide (GIP), and = glucagon-like=20 peptide 1 (GLP-1).

Results:The insulin responses were higher after both = breakfast=20 (31%) and lunch (57%) when whey was included in the meal than = when whey was not included. After lunch, the blood glucose = response=20 was significantly reduced [=9621%; 120 min area under the = curve=20 (AUC)] after whey ingestion. Postprandial GIP responses were = higher=20 after whey ingestion, whereas no differences were found in = GLP-1=20 between the reference and test meals.

Conclusions:It can be concluded that the addition of whey = to=20 meals with rapidly digested and absorbed carbohydrates = stimulates=20 insulin release and reduces postprandial blood glucose = excursion=20 after a lunch meal consisting of mashed potatoes and = meatballs=20 in type 2 diabetic subjects.

Key Words: Milk =95 whey =95 type 2 diabetes =95 = blood glucose =95=20 serum insulin =95 incretin hormones=20





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